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Alzheimers Disease Type 3 Diabetes
Earlier this year, researchers reported finding insulin being produced in an organ other than the pancreas:
The amounts were low. But the idea that Alzheimers Disease (AD) could be a form of diabetes specific to the central nervous system prompted additional study. Subsequently, a supportive follow-up report was published in November that described a link between the progressive nature of AD and the availability of insulin and insulin-like growth factors - the lower the quantity of insulin and functioning insulin receptors in the brain, the more advanced was the stage of AD.
The type of diabetes described here as associated with Alzheimers Disease (coined "type 3 diabetes" by researchers) is not the same as type 2 diabetes, which affects approximately 18 million Americans. Type 2 diabetes is characterized by higher than normal levels of blood glucose (throughout the body) which result from malfunctions in the production or utilization of insulin made in the pancreas.
A connection between the two disorders may exist, but has yet to be clarified. If a relationship can be shown, the possibilities for therapies that could target both type 2 diabetes and Alzheimers Disease are promising.
________
For press release on "brain insulin" finding:
Researchers discover link between insulin and Alzheimers
For some summaries of the recent study:
Evidence Grows That Alzheimers Is A Type Of Diabetes
and
Alzheimers Disease May Be Type 3 Diabetes
For the abstract and review article:
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimers disease
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimers disease - is this type 3 diabetes?
Alzheimers Disease Type 3 Diabetes
Sunday, January 19, 2014
Earlier this year, researchers reported finding insulin being produced in an organ other than the pancreas:"Researchers at Rhode Island Hospital and Brown Medical School have discovered that insulin and its related proteins are produced in the brain, and that reduced levels of both are linked to Alzheimers disease."
The amounts were low. But the idea that Alzheimers Disease (AD) could be a form of diabetes specific to the central nervous system prompted additional study. Subsequently, a supportive follow-up report was published in November that described a link between the progressive nature of AD and the availability of insulin and insulin-like growth factors - the lower the quantity of insulin and functioning insulin receptors in the brain, the more advanced was the stage of AD.
The type of diabetes described here as associated with Alzheimers Disease (coined "type 3 diabetes" by researchers) is not the same as type 2 diabetes, which affects approximately 18 million Americans. Type 2 diabetes is characterized by higher than normal levels of blood glucose (throughout the body) which result from malfunctions in the production or utilization of insulin made in the pancreas.
A connection between the two disorders may exist, but has yet to be clarified. If a relationship can be shown, the possibilities for therapies that could target both type 2 diabetes and Alzheimers Disease are promising.
For press release on "brain insulin" finding:
Researchers discover link between insulin and Alzheimers
For some summaries of the recent study:
Evidence Grows That Alzheimers Is A Type Of Diabetes
and
Alzheimers Disease May Be Type 3 Diabetes
For the abstract and review article:
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimers disease
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimers disease - is this type 3 diabetes?
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