Showing posts with label response. Show all posts
Showing posts with label response. Show all posts

Green Vegetables Stimulate the Innate Immune Response to Guard against Disease

Tuesday, April 22, 2014


We all know that our immune system is the first line of defense against a wide array of potentially deadly pathogens, bacteria and viruses. Yet many people take this crucial defense barrier for granted and do little to ensure that they are adequately protected against a multitude of microscopic invaders.

Researchers publishing the result of a research body performed at the University of Cambridge in the journalCell demonstrate that compounds found in green vegetables, from bok choy to broccoli are the source of a chemical signal that is important to activate a fully functioning immune system. Help protect yourself and your family from maladies ranging from the common cold, influenza to autoimmune diseases and certain cancers by including healthy portions of green vegetables in your daily diet.

Include Ten or More Fresh Vegetable Servings Daily to Boost Immune Health
Prior research indicated the breakdown of cruciferous vegetables can yield a compound that can be converted into a molecule that triggers the aryl hydrocarbon receptor (AhR) on cell wall surfaces. Further reports found AhR’s can be regulated by dietary ingredients found primarily in vegetables including broccoli, kale, spinach and many varieties of leafy greens. This action ensures that immune cells in the gut and the skin known as intra-epithelial lymphocytes (IELs) function properly.

Researchers fed otherwise healthy mice a vegetable-poor diet for several weeks were amazed to find that 70 to 80 percent of these protective IEL cells disappeared during this short period. Dr. Marc Veldhoen, lead study author notedthat, “protective IELs exist as a network beneath the barrier of epithelial cells covering inner and outer body surfaces, where they are important as a first line of defense and in wound repair.”It was determined the number of IEL cells can be regulated by dietary ingredients found primarily in cruciferous vegetables.

A Diet High in Sugar and Processed Carbohydrates Lowers System Immune Response
Poor dietary intake consisting mostly of hydrogenated and oxidized fats, sugar and processed foods directly alters the surface receptors of cells lining the digestive tract, responsible for more than 80 percent of our immune response. Researchers commented“individuals fed a synthetic diet lacking this key compound experience a significant reduction in AhR activity and lose IELs. With reduced numbers of these key immune cells, individuals showed lower levels of antimicrobial proteins, heightened immune activation and greater susceptibility to injury.”

Dr. Veldhoen concluded"its already a good idea to eat your greens… the results offer a molecular basis for the importance of cruciferous vegetable-derived phyto-nutrients as part of a healthy diet.”The current recommendation to eat 3 to 5 servings of vegetables and fruit each day is anemic and insufficient in the light of this important study. Health-minded people will want to include fresh, raw greens at the core of their diet and include 10 or more generous servings each day to boost immune health.
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Omega 3 Fats Found in Fish Oil Boost Immune Response to Help Fight Inflammation and Disease

Friday, February 21, 2014

Most people take a healthy immune response for granted, as it typically remains on guard detecting a host of known and as yet unidentified pathogens that may threaten our health. Bacteria and viruses that cause the common cold, flu, digestive distress and a variety of potentially fatal illnesses are identified and destroyed before they cause more than a minor discomfort. For most of the past decade, fish consumption and supplementing with DHA and EPA fortified supplements has been shown to lower levels of systemic inflammation and significantly reduce the risk of developing many cancers, stroke and cardiovascular disease, yet the precise mechanism of action has been unknown.

Fish Oil Fats, DHA and EPA Stimulate Immune System B cells to Fight Inflammation and Disease Risk
A group of researchers from the Department of Food Science and Human Nutrition at Michigan State University have published the result of their work in the Journal of Leukocyte Biology that shows how DHA-rich fish oil enhances B cell activity, a white blood cell that is critical to activate our immune response. One of the study authors, Dr. Jennifer Fenton explained “Fish oil may have immune enhancing properties that could benefit immunocompromised individuals.”

Omega-3 fat sources including fish oil include the long chain fatty acids, DHA and EPA that have been shown in a number of prior studies to reduce total body inflammation that help to lower the risk of developing many chronic illnesses including cancer, heart disease, dementia and stroke. Researchers now uncover how these special fats enhance B-cell activity, a white blood component necessary to improve immune system activity and lower inflammatory response.

Supplement Daily with A Distilled Fish Oil Capsule to Squelch Inflammation and Lower Disease Risk
Researchers used two mouse models to conduct their study, one group was fed a control diet and the other was fed a diet supplemented with DHA-rich fish oil for a period of five weeks. B cells were taken from various tissues and the scientists then looked for markers of B cell activation on the cell surface, B cell membrane changes, and B cell cytokine production to assess immune response activation.

The team found that those mice supplemented with DHA-enriched fish oil demonstrated B cell activation and antibody production to aid immune response and pathogen clearance, while damping systemic inflammation. The authors concluded “This work confirms similar findings on fish oil and B cells… and moves us one step closer to understanding the immune enhancing properties of EPA and DHA.” Adults should supplement with a distilled fish oil preparation (1,200 to 2,400 mg EPA/DHA per day) to fight inflammation and heighten immune system response.
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