Beauty Health for Life

Health conscious individuals have been closely following Vitamin D research for the past decade as volumes of scientific evidence prove this prohormone has been selected through our evolution to provide critical protection against many inflammatory and immune mediated diseases.

Earlier this year, a study in the American Heart Associations journal Circulation reported an increased risk of heart attack with use of nonsteroidal anti-inflammatory drugs (NSAIDs) in healthy individuals (over 1 million individuals included in the analysis).¹ It wasnt the first study to find this risk with NSAIDS; however, prior studies looked at those who had heart disease or were at increased risk for it, not apparently healthy people.

Last month at the European Society of Cardiologys 2010 Congress, the same authors reported an increased risk for stroke with use of NSAIDS in a similar large and healthy Danish population. Speaking to Heartwire, Dr. Gunnar Gislason, one of the authors said:

"This is very serious, as these drugs are very widely used, with many available over the counter. ... We need to get the message out to healthcare authorities that these drugs need to be regulated more caully."

Gislason thinks NSAIDS need better management, perring they not be available without a prescription:

"If half the population takes these drugs, even on an occasional basis, then this could be responsible for a 50% to 100% increase in stroke risk. It is an enormous effect."

Examples of NSAIDS currently available in the US without prescription are ibuprofen (e.g. Motrin and Advil) and naproxen (Aleve). Diclofenac (e.g. Voltaren and Cataflam), celecoxib (Celebrex), and rofecoxib (Vioxx, now withdrawn) are NSAIDS that require a prescription.

Mechanism

NSAIDS are thought to increase cardiovascular and cerebrovascular risk via:

• Increased coagulative effect, with risk of thrombus.
  
• Increased bleeding, especially associated with stroke.
  
• Increased blood pressure. (This is an effect of all NSAIDS.)²
  
• Adverse effects on kidneys. (NSAIDS can lead to sodium and water retention, and a decrease in glomerular filtration rate (GFR).)³

Sometimes benefit outweighs risk. NSAIDS are effective pain relievers. The decision to start NSAIDs should be based on an individuals cardiovascular risk and the specific need for pain relief.
________
¹ Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals, Circulation, 2010
² NSAIDs, Coxibs, and Cardio-Renal Physiology: A Mechanism-Based Evaluation: Coxibs and Hypertension, Medscape, 2002
³ Renal Effects Of Cyclooxygyenase-2-Selective Inhibitors, Journal of Pain and Symptom Management, 2002

"[NSAIDS] are associated with adverse renal effects caused by the reduction in synthesis of renal prostaglandins through inhibition of cyclooxygenase (COX)."

Fish oil supplements may protect the heart in stressful situations, according to a recent study. Jason Carter, a researcher at Michigan Technological University, conducted the study with 67 healthy volunteer test participants in their 20s. Over a 2-month period, they were either given nine grams of fish oil pills or nine grams of olive oil as a placebo.

The test subjects were screened for heart rate, blood pressure and other related metrics. At the end of the test period, both groups took a mental arithmetic test that involved adding and subtracting numbers in their head. Their stress response was measured at that time.

“Those in the fish oil group showed blunted heart rate reactivity while they were stressed compared to those who took olive oil," said Carter. "Similarly, the total [muscle sympathetic nerve activity] reactivity to mental stress was also blunted in the fish oil group.” There was not much difference between the two groups at rest, however.
Results of the study were published in the May edition of the American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology, published by the American Physiological Society. It is available online at http://bit.ly/10j0CSS

Male pattern baldness is linked to an increased risk of coronary heart disease, but only if its on the top/crown of the head, rather than at the front, finds an analysis of published evidence in the online journal BMJ Open.

A receding hairline is not linked to an increased risk, the analysis indicates.

The researchers trawled the Medline and the Cochrane Library databases for research published on male pattern baldness and coronary heart disease, and came up with 850 possible studies, published between 1950 and 2012.

But only six satisfied all the eligibility criteria and so were included in the analysis. All had been published between 1993 and 2008, and involved just under 40,000 men.

Three of the studies were cohort studies - meaning that the health of balding men was tracked for at least 11 years.

Analysis of the findings from these showed that men who had lost most of their hair were a third more likely (32%) to develop coronary artery disease than their peers who retained a full head of hair.

When the analysis was confined to men under the age of 55-60, a similar pattern emerged. Bald or extensively balding men were 44% more likely to develop coronary artery disease.

Analysis of the other three studies, which compared the heart health of those who were bald / balding with those who were not, painted a similar picture.

It showed that balding men were 70% more likely to have heart disease, and those in younger age groups were 84% more likely to do so.

Three studies assessed the degree of baldness using a validated scale (Hamilton scale). Analysis of these results indicated that the risk of coronary artery disease depended on baldness severity, but only if this was on the top/crown of the head, known as the vertex.

Extensive vertex baldness boosted the risk by 48%, moderate vertex baldness by 36%, and mild vertex baldness by 18%. By contrast, a receding hairline made very little difference to risk, the analysis showed.

To compensate for differences in the methods of assessing baldness in the studies included in the analysis, the authors looked at four differing grades of baldness: none; frontal; crown-top; combined.

Once again, this indicated that the severity of baldness affected the risk of coronary heart disease.

Men with both frontal and crown-top baldness were 69% more likely to have coronary artery disease than those with a full head of hair, while those with just crown-top baldness were 52% more likely to do so. Those with just frontal baldness were 22% more likely to do so.

Explanations for the reasons behind the association vary, but include the possibility that baldness may indicate insulin resistance, a precursor to diabetes; a state of chronic inflammation; or increased sensitivity to testosterone, all of which are involved directly or indirectly in promoting cardiovascular disease, say the authors.

But they conclude: "[Our] findings suggest that vertex baldness is more closely associated with systemic atherosclerosis than with frontal baldness. Thus, cardiovascular risk factors should be reviewed caully in men with vertex baldness, especially younger men" who should "probably be encouraged to improve their cardiovascular risk profile."

Prospective study finds clinically significant difference in atherosclerosis progression based on changes in periodontal health

Taking care of your gums by brushing, flossing, and regular dental visits could help hold heart disease at bay. Researchers at Columbia Universitys Mailman School of Public Health have shown for the first time that as gum health improves, progression of atherosclerosis slows to a clinically significant degree. Findings appear online in the Journal of the American Heart Association.

Artherosclerosis, or the narrowing of arteries through the build-up of plaque, is a major risk factor for heart disease, stroke, and death.

"These results are important because atherosclerosis progressed in parallel with both clinical periodontal disease and the bacterial profiles in the gums. This is the most direct evidence yet that modifying the periodontal bacterial profile could play a role in preventing or slowing both diseases," says Moïse Desvarieux, MD, PhD, lead author of the paper and associate professor of Epidemiology at the Mailman School.

The researchers followed 420 adults as part of the Oral Infections and Vascular Disease Epidemiology Study (INVEST), a randomly sampled prospective cohort of Northern Manhattan residents. Participants were examined for periodontal infection. Overall, 5,008 plaque samples were taken from several teeth, beneath the gum, and analyzed for 11 bacterial strains linked to periodontal disease and seven control bacteria. Fluid around the gums was sampled to assess levels of Interleukin-1β, a marker of inflammation. Atherosclerosis in both carotid arteries was measured using high-resolution ultrasound.

Over a median follow-up period of three years, the researchers found that improvement in periodontal health—health of the gums—and a reduction in the proportion of specific bacteria linked to periodontal disease correlated to a slower intima-medial thickness (IMT) progression, and worsening periodontal infections paralleled the progression of IMT. Results were adjusted for potential confounders such as body mass index, cholesterol levels, diabetes, and smoking status,

Clinical Significance

There was a 0.1 mm difference in IMT change over three years among study participants whose periodontal health was deteriorating compared with those whose periodontal health was improving. Previous research has shown that a .033 mm/year increase in carotid IMT (equivalent to approximately 0.1 mm over three years) is associated with a 2.3-fold increased risk for coronary events.

"When it comes to atherosclerosis, a tenth of a millimeter in the thickness of the carotid artery is a big deal. Based on prior research, it appears to meet the threshold of clinical significance," says Tatjana Rundek, MD, PhD, a co-author of the study and professor at the University of Miami whose lab read the carotid ultrasounds.

Even subtle changes to periodontal status had a dose-response relationship to carotid IMT. "Our results show a clear relationship between what is happening in the mouth and thickening of the carotid artery, even before the onset of full-fledged periodontal disease," says co-author Panos N. Papapanou, DDS, PhD, professor of Dental Medicine at Columbia Universitys College of Dental Medicine, whose laboratory assessed the bacterial profiles in the gums. "This suggests that incipient periodontal disease should not be ignored."

Bacteria in the mouth may contribute to the onset of atherosclerosis in a number of ways, scientists speculate. Animal studies indicate that they may trigger immune response and high levels of inflammatory markers, which may initiate or exacerbate the inflammatory aspect of atherosclerosis.

The results build on previous findings. In earlier cross-sectional results, Dr. Desvarieux and colleagues had reported that higher levels of disease-causing bacteria were associated with thicker IMT. The current study takes the next step by looking at the cohort over time.

"Our results address a gap identified in the AHA statement on periodontal disease and atherosclerosis, by providing longitudinal data supporting this association," says study co-author Ralph Sacco, MD, professor and chairman of Neurology at the University of Miami, Miller School of Medicine and former president of the American Heart Association. Concludes Dr. Desvarieux, "It is critical that we continue to follow these patients to see if the relationship between periodontal infections and atherosclerosis carries over to clinical events like heart attack and stroke and test if modifying the periodontal flora will slow the progression of atherosclerosis."

A new study by the Centers for Disease Control and Prevention (CDC) links too little sleep (six hours or less) and too much sleep (10 or more hours) with chronic diseases – including coronary heart disease, diabetes, anxiety and obesity – in adults age 45 and older. The American Academy of Sleep Medicine (AASM) encourages patients suffering from these common chronic conditions to speak with a sleep medicine physician who can evaluate their sleep patterns.

“It’s critical that adults aim for seven to nine hours of sleep each night to receive the health benefits of sleep, but this is especially true for those battling a chronic condition,” said Dr. M. Safwan Badr, president of the AASM. “Common sleep illnesses – including sleep apnea and insomnia – occur frequently in people with a chronic disease and can hinder your ability to sleep soundly. So if you’re waking up exhausted, speak with a sleep physician to see if there’s a problem. If you are diagnosed with a sleep illness, treating it could significantly improve disease symptoms and your quality of life.”

“Some of the relationships between unhealthy sleep durations and chronic diseases were partially explained by frequent mental distress and obesity,” said study co-author Janet B. Croft, PhD, senior chronic disease epidemiologist in CDC’s Division of Population Health. “This suggests that physicians should consider monitoring mental health and body weight in addition to sleep health for patients with chronic diseases.”

In the study, published in the October issue of the Journal SLEEP, short sleepers reported a higher prevalence of coronary heart disease, stroke and diabetes, in addition to obesity and frequent mental distress, compared with optimal sleepers who reported sleeping seven to nine hours on average in a 24-hour period. The same was true for long sleepers, and the associations with coronary heart disease, stroke and diabetes were even more pronounced with more sleep.

“Sleeping longer doesn’t necessarily mean you’re sleeping well. It is important to understand that both the quality and quantity of sleep impact your health,” said Badr. “A healthy, balanced lifestyle is not limited to diet and fitness; when and how you sleep is just as important as what you eat or how you exercise.”

The study involved more than 54,000 participants age 45 or older in 14 states. Nearly one third of participants (31 percent) were identified as short sleepers, meaning they reported sleeping six hours or less on average. More than 64 percent were classified as optimal sleepers, and only 4 percent of participants were long sleepers.

Simple Ways of Maintaining Healthy Heart | Health problems can not be underestimated in the heart of the present. We must consider our health, especially heart health. Keeping the heart healthy way is actually quite simple. World Heart Federation (World Heart Federation/WHF) estimates that cardiovascular disease will be the leading cause of death in Asia in 2010. Below, there are some Simple Ways of Maintaining Healthy Heart, among others:

1. Adjusting diet
a. Try eating more foods such as rice, vegetables (green beans, spinach, etc.), fruits, fish, grains and yogurt.

b. Reduce your intake of foods such as milk, cheese and nuts. Add garlic to your recipes.

c. Eating foods that contain beta-carotene such as carrots, cabbage and root crops.

d. Reduce intake of sodium, no more than a quarter teaspoon of salt a day. Eat regular meals. Drinking enough water. Change the habit of drinking coffee with tea.

2. Changing patterns and lifestyles
a. Regular exercise. At first choose the type of mild to moderate intensity exercise such as brisk walking, or bike that carried at least 30 minutes three to five times a week. Get used to using the stairs on each to go up to higher floors.

b. Take advantage of every opportunity to perform physical activity. If you drive a motor vehicle, try to park a little farther from your destination so that you get used to walking.

c. Doing chores such as sweeping, mopping, cleaning the house in addition to your sport. Maintain your ideal weight.

d. Stop smoking and avoid alcohol.

e. Get plenty of rest. Organize your daily schedule to avoid stress.

f. Do it a useful exercise to reduce stress such as relaxation therapy, yoga and meditation. Lots of laughing is good medicine.

3. Check your health on a regular basis
a. Know history of heart disease and blood vessels in your family tree.

b. Perform regular medical check ups, including the monitoring of blood pressure and cholesterol your body.

4. Take the medication that was prescribed by a doctor for you

5. Give and receive affection from the people you care about

Try applying some basic tips above in your daily life, for the most appropriate treatment for heart disease is actually prevented heart disease itself.

May this Simple Ways of Maintaining healthy Heart could be beneficial to you. You can also read How To Keep Young Pregnancy. Good luck.