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Acne keloidalis nuchae and genetic predisposition

Friday, November 2, 2012

Individuals with Acne keloidalis nuchae are likely to be genetically predisposed to the condition. Researchers are not completely clear about exactly how genes relate to AKN. However, there are some nominations likely.There is a documented case of a 27-year-old man who was diagnosed with Keratosis Follicularis Spinulosa Decalvans and Acne keloidalis nuchae.  (MS Goh, Mark J Chong & AH-Saint Vincent Hospital in Melbourne in Australia) Keratosis Follicularis Spinulosa Decalvans is an X linked disorder that is characterized by a high level of kerain in hair follicles, resulting in cone-shaped papules. The correlation of the two conditions suggests a clinical correlation.


A genetic predisposition to Acne keloidalis nuchae can also be related with a high concentration of mast cells in the occipital region of the scalp. Mast cells are a type of white blood cells, also known as leukocytes. They are part of the immune system. These cells initiate inflammatory responses in reaction to foreign invaders like germs. With Acne keloidalis nuchae, the cells are not able to recognize the strands of hair as being native to the body and attack the hair follicles.


Although the manifestation of AKN may have its origins in the genetic makeup of the individual, this does not mean that there is no hope for treatment. Early intervention in the form of topical or oral medication can help the condition to progress to advanced stages. The Nd: YAG laser has also shown promise in being able to improve the symptoms of Acne keloidalis nuchae, removing the axes problem hair follicles. And even the most severe cases of acne Keloidalis Nuchae can be eliminated through proper techniques to surgically excise the enlarged mass of tissue at the back of the patient's head. The choice of treatment depends on the clinical stage of the disease.




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